Synthesis, antimicrobial and computational studies of natural products derivatives of tricarbonyl (2-methoxycyclohexadienyl)iron tetrafluoroborate salt: An alternative route to natural products modification

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Poster

Synthesis, antimicrobial and computational studies of natural products derivatives of tricarbonyl (2-methoxycyclohexadienyl)iron tetrafluoroborate salt: An alternative route to natural products modification

Authors

T Eugene-Osoikhia¹; IA Oladosu²; NO Obi-Egbedi³; TI Odiaka³;
¹ University of East Anglia, UK; ² The University of Ibadan, Nigeria; ³ Department of Chemistry, University of Ibadan, Nigeria

Discussion

Authors

T Eugene-Osoikhia¹; IA Oladosu²; NO Obi-Egbedi³; TI Odiaka³;
¹ University of East Anglia, UK; ² The University of Ibadan, Nigeria; ³ Department of Chemistry, University of Ibadan, Nigeria

Discussion

Biologically active natural products addition to [(1-5-η-2-MeOC₆H₆) Fe(CO)₃][BF₄] has resulted in its 1,3-diene substituted derivatives. The subsequent removal of the tricarbonyliron moiety of these derivatives through demetallation with trimthylamine-N-oxide (Me₃NO), gave new organic compounds with enhanced antimicrobial properties as supported by quantum descriptors and QSAR measurements.