Screening multiple PPI targets in parallel: accelerating portfolio-level decisions

Programme : Back to Miss Julie Vann

Poster

119

Screening multiple PPI targets in parallel: accelerating portfolio-level decisions

Authors

G Mahe¹; P Kelly²; P Winship²; J Spencer²; J van Offenbeek¹; K Nash²; M Vlaming¹;
¹ Charles River Laboratories, NL, Netherlands; ² Charles River Laboratories, UK, UK

Discussion

Authors

G Mahe¹; P Kelly²; P Winship²; J Spencer²; J van Offenbeek¹; K Nash²; M Vlaming¹;
¹ Charles River Laboratories, NL, Netherlands; ² Charles River Laboratories, UK, UK

Discussion

HTS projects for multiple targets were developed in collaboration with our client and performed in parallel in a cross-site collaboration. Up to 370,000 compounds from a variety of chemical libraries were screened in a 1536-well plate format using TRFRET technology. During screening, plate effects were observed and investigated, the cause was attributed to shipment of assay ready plates on dry-ice.