Authors

Discussion

Several human neurodegenerative diseases share a common pathological feature: the formation and accumulation of prion-like aberrant protein aggregates and insoluble inclusions, which lead to progressive neuronal dysfunction and toxicity.  Here we present a multilayer platform to address TDP43 dysfunctions, a protein involved in RNA processing and the onset of pathological aggregates, using imaging, optogenetic assays, high-throughput miniaturized formats and relevant cell models, as a proof-of-concept to approach different neuro-related disorders and establishing the basis for therapeutic strategies .