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Poster
45

An integrated platform for drug screening of neurological disease models

Authors

H Mollica1; P Bonetti1; K Montag1; L Rutigliano1; S Cainarca1; P Tarroni1; L Scarabottolo1; S Lohmer1F Ricci1
1 Axxam SpA, Italy

Discussion

Authors

H Mollica1; P Bonetti1; K Montag1; L Rutigliano1; S Cainarca1; P Tarroni1; L Scarabottolo1; S Lohmer1F Ricci1
1 Axxam SpA, Italy

Discussion

Several human neurodegenerative diseases share a common pathological feature: the formation and accumulation of prion-like aberrant protein aggregates and insoluble inclusions, which lead to progressive neuronal dysfunction and toxicity.  Here we present a multilayer platform to address TDP43 dysfunctions, a protein involved in RNA processing and the onset of pathological aggregates, using imaging, optogenetic assays, high-throughput miniaturized formats and relevant cell models, as a proof-of-concept to approach different neuro-related disorders and establishing the basis for therapeutic strategies .