Authors

P McIntyre¹; 
¹ Charnwood Molecular, UK

Discussion

PROteolysis-TArgeting Chimeras (PROTACs) are an exciting new development in drug discovery that have the potential to modulate protein targets once considered ‘undruggable’. At Charnwood Molecular we utilise SPR on our Biacore 8K system to measure important insights into the binding behaviour of PROTAC – and other – molecules to their target proteins. 

The ability to characterise an interaction can be critical for deciding how to progress a project. 

In this work we demonstrate several such of our capabilities here at Charnwood Molecular: 

· Assay development for SPR experiments – using literature precedent (where possible) to design and develop SPR screening assays for new protein targets. 

· Mechanistic insights into interactions between small molecules and protein – SPR is a powerful technique that can help us infer subtle details about a biomolecular interaction. · As well as PROTAC drug discovery, these techniques can be applied to other more general aspects of drug discovery and screening.